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Computational models for functional genomics
We use molecular biology techniques and animal models to study the immune response to pathogenic infection. We also augment these methods with in silico analytical techniques such as transcriptional profiling and computational modeling. While many commercially available programs exist for the functional analysis of mammalian transcriptional profiles, analysis of this kind is not readily available for insect models. We have developed a Gene Set Enrichment Analysis (GSEA) tool for Drosophila datasets, allowing us to functionally characterize how functional categories of genes are being regulated upon infection (Martin and Hiroyasu et al., 2018; Ahlers et al., 2019).
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